Spider-Man 4, featuring Tom Holland, has been confirmed, but details about the plot are being kept secret by Marvel. Industry scooper Alex Perez suggested that the movie will be a team-up film similar to Deadpool & Wolverine, with Andrew Garfield and Tobey Maguire potentially returning in larger roles. Perez also hinted at the inclusion of characters like Doctor Doom, Mephisto, Ghost Rider, Knull, Venom, and Daredevil in the upcoming movie. The insider mentioned that Tom Hardy's Venom could be paired with Holland's Spider-Man, leading to a possible showdown with Knull as the final antagonist. Additionally, Perez discussed the potential involvement of Mephisto and Ghost Rider in the storyline, hinting at a connection to the Avengers: Doomsday arc and the One More Day comic storyline.
Source: https://www.superherohype.com/news/589853-spider-man-4-andrew-garfield-tobey-maguire-deadpool-wolverine-rumor