The Kentucky Derby, a showcase of equine athleticism, highlights the remarkable characteristics of horses that have evolved over millennia for survival. Horses possess big hearts, immense lung capacity, robust musculoskeletal systems, and long, thin legs, enabling them to excel in various activities. Their extraordinary cardiovascular system, lung capacity, and genetic mutations contribute to their athletic prowess. Despite their adaptations for speed and agility, horses are prone to injuries due to the repetitive stress of racing and training. Efforts to improve equine safety and reduce fatalities in horse racing have shown some progress, but the factors that make certain horses exceptional remain a mystery.