Christina Applegate opened up about her struggles with multiple sclerosis in a podcast interview with Conan O’Brien. She described her daily life with the disease, revealing that she rarely leaves the house and faces challenges like walking on needles and hot lava. Applegate discussed the stigma surrounding MS and how people often assume she did something to cause it. She shared her initial symptoms and diagnosis process, highlighting the pain and numbness she experienced. Despite the challenges, she remains determined to manage her symptoms and live her life to the best of her ability.