Clade I Mpox Cases Confirmed in Los Angeles County: Symptoms, Transmission, and Vaccination Information

Two cases of a potentially more severe strain of mpox have been confirmed in Los Angeles County this week. This particular type of mpox, known as "Clade I," has been found in the United States for the first time among individuals who did not travel to high-risk areas overseas. The first case was reported in a Long Beach resident, while the second case was reported in another person in Los Angeles County. Both patients required hospitalization but are now recovering at home, according to health officials.
Clade I mpox is distinct from the global outbreak strain of 2022, known as "Clade II." Clade I is considered more concerning as it may cause more severe illness and spread more easily through close personal contact, including massage, cuddling, and sex, as stated by the L.A. County Department of Public Health.
Symptoms of mpox include rash, sores resembling pimples or blisters, fever, chills, headache, muscle aches, and swelling of lymph nodes. Individuals experiencing these symptoms are advised to seek medical evaluation promptly and avoid intimate contact. Testing is recommended for those with symptoms, and individuals should refrain from sex or close contact.
Clade II mpox typically results in mild-to-moderate illness and has been circulating at low levels in the U.S. since 2022. Prior to this week, there were six cases of Clade I mpox in the U.S., all linked to recent travel to central and eastern Africa. The risk of Clade I mpox transmission in the general U.S. population is considered low, with more than 40,000 cases reported in central and eastern Africa.
The Jynneos vaccine is available to prevent the spread of mpox, with two doses recommended. Individuals who have only received one dose can still get their second dose, regardless of the time elapsed since the first dose. Vaccination is encouraged for those at higher risk of infection, including individuals exposed to an infected person, gay and bisexual men, transgender individuals, people with HIV, travelers to high-risk areas, and those with occupational risks.
Vaccination sites can be found at pharmacies like Walgreens and CVS, and individuals can locate vaccination locations through the vaccine manufacturer or the L.A. County Department of Public Health. It is crucial to prioritize vaccination to prevent the spread of mpox and protect individuals at higher risk of infection.